中国中药杂志

2017, v.42(05) 856-862

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白术芍药散治疗溃疡性结肠炎研究进展
Research progress of Baizhu Shaoyao powder in treating ulcerative colitis

徐洋洋;蔡皓;段煜;裴科;范恺磊;刘晓;曹岗;
XU Yang-yang;CAI Hao;DUAN Yu;PEI Ke;FAN Kai-lei;LIU Xiao;CAO Gang;School of Pharmacy,Nanjing University of Chinese Medicine;Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing,Nanjing University of Chinese Medicine;Institute of Pharmaceutical and Food Engineering,Shanxi University of Traditional Chinese Medicine;Research Center of Traditional Chinese Medicine Processing Technology,Zhejiang Chinese Medical University;

摘要(Abstract):

溃疡性结肠炎是一种慢性非特异性的复杂性肠道疾病,目前临床治疗以口服西药为主,包括氨基水杨酸、糖皮质激素和免疫抑制剂类,但因其疗效不稳定、毒性大和依赖性强等问题的存在,不适合长期使用。白术芍药散是临床常用的中医传统方剂,具有补脾柔肝和祛湿止泻的功效。现代研究表明,白术芍药散在治疗溃疡性结肠炎方面表现出良好的疗效。该文就白术芍药散治疗溃疡性结肠炎的疗效及作用机制的研究进展进行了综述,并为今后的进一步研究提出了思路和方向。
Ulcerative colitis is a chronic,nonspecific and complex intestinal disease. The current clinical treatment guideline of this disease recommends a variety of options with oral western medicines,such as aminosalicylic acids,glucocorticosteroids,and immunosuppressors. However,due to their unstable therapeutic effects,high toxicities,and strong drug dependence,they are not suitable for long-term administration. Baizhu Shaoyao powder,a traditional Chinese medicinal prescription,is clinically and commonly used for tonifying spleen and softening liver as well as eliminating dampness and relieving diarrhea. Recent researches suggest that Baizhu Shaoyao powder has significant effect in the treatment of ulcerative colitis. This article reviewed the research progress on the curative effect and action mechanism of Baizhu Shaoyao powder in treating ulcerative colitis,and provided the ideas and directions for its further research in future.

关键词(KeyWords): 白术芍药散;溃疡性结肠炎;治疗机制;研究进展
Baizhu Shaoyao powder;ulcerative colitis;therapeutic mechanism;research progress

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81573602,81673600)

作者(Author): 徐洋洋;蔡皓;段煜;裴科;范恺磊;刘晓;曹岗;
XU Yang-yang;CAI Hao;DUAN Yu;PEI Ke;FAN Kai-lei;LIU Xiao;CAO Gang;School of Pharmacy,Nanjing University of Chinese Medicine;Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing,Nanjing University of Chinese Medicine;Institute of Pharmaceutical and Food Engineering,Shanxi University of Traditional Chinese Medicine;Research Center of Traditional Chinese Medicine Processing Technology,Zhejiang Chinese Medical University;

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DOI: 10.19540/j.cnki.cjcmm.20170121.005

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