中国中药杂志

2020, v.45(02) 267-273

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基于针刺压力传感器的人参润制“药透水尽”科学内涵研究
Mechanism of "herb soaking with exact amount of water" during moistening process of ginseng based on needle pressure sensor

连传运;徐冰;赵亚楠;戴胜云;侯金才;张燕玲;乔延江;
LIAN Chuan-yun;XU Bing;ZHAO Ya-nan;DAI Sheng-yun;HOU Jin-cai;ZHANG Yan-ling;QIAO Yan-jiang;Department of Chinese Medicine Information Science, Beijing University of Chinese Medicine;National Institutes for Food and Drug Control;Shenwei Pharmaceutical Group Co., Ltd.;

摘要(Abstract):

采用质构仪针刺式压力传感器对人参润制"药透水尽"进行客观化表征。先采用单因素轮换试验,考察穿刺速度、穿刺深度和穿刺部位对穿刺力和做功的影响。按照《中国药典》人参炮制方法,选择直径约1 cm和2 cm的人参药材,在设定的测定时间点进行穿刺试验,测定人参的硬度、吸水率和穿刺针做功随时间的变化,结合经验判断制订人参软化过程终点阈值,并进行验证。为反映人参软化过程药材内部真实情况,穿刺深度优选为70%,穿刺速度为30 mm·min~(-1)。人参润制过程中,软化硬度变化符合一级动力学方程y=a×exp(-k×x),1 cm和2 cm的人参药材的0 h初始硬度a分别为289.8,1 227 N,速率常数k分别为0.149 4,0.100 7 N·h~(-1)。人参完全软化后,穿刺所需力为10 N,可以作为"药透"的标准,此时人参的吸水率70%~100%。直径1 cm人参软化时间为20~22 h,直径2 cm人参软化时间为40~46 h。采用针刺式压力传感器,有助于精确判断人参润制软化过程终点,减少有效成分损失。研究结果为其他干燥根及根茎类药材软化过程动力学研究和过程智能监控提供参考。
In this study, the texture analyzer acupuncture pressure sensor was used to objectively characterize the "herb soaking with exact amount of water" for moistening process of ginseng. The single factor rotation experiment was used to investigate the effects of puncture speed, puncture depth and puncture site on puncture force and work. According to ginseng processing method in Chinese Pharmacopoeia, ginseng medicinal materials with diameters of about 1 cm and 2 cm were selected, and puncture experiments were carried out at the set measurement time to determine the hardness, work and water absorption of the ginseng moistening process. The endpoint threshold for the ginseng softening process was determined and verified. To reflect the actual internal conditions of the ginseng softening process, the puncture depth was preferably 70%, and the puncture speed was 30 mm·min~(-1). In the ginseng moistening process, the softening hardness and the puncture work were in accordance with the first-order kinetic equation y=a×exp(-k×x). The 0 h initial hardness a of 1 cm and 2 cm ginseng herbs were 289.8 N and 1 227 N, and the rate constants K were 0.149 4 N·h~(-1) and 0.100 7 N·h~(-1), respectively. After the ginseng was completely softened, the force required for puncture was 10 N, which can be used as the standard for "drug penetration". At this time, the water absorption rate of ginseng was 70%-100%. The softening time of ginseng with a diameter of 1 cm was about 20-22 h, and the softening time of ginseng with a diameter of 2 cm was about 40-46 h. A needle-type pressure sensor was used to accurately determine the end point of the softening process of ginseng and reduce the loss of active ingredients. The study results provide reference for the softening process kinetics and the process intelligent monitoring of other dried roots and rhizomes.

关键词(KeyWords): 人参;润制过程;药透水尽;压力传感器;一级动力学
ginseng;moistening process;herb soaking with exact amount of water;pressure sensor;first order dynamics

Abstract:

Keywords:

基金项目(Foundation): 北京中医药大学科研项目(2019-JYB-JS-015);; 国家自然科学基金项目(81403112)

作者(Author): 连传运;徐冰;赵亚楠;戴胜云;侯金才;张燕玲;乔延江;
LIAN Chuan-yun;XU Bing;ZHAO Ya-nan;DAI Sheng-yun;HOU Jin-cai;ZHANG Yan-ling;QIAO Yan-jiang;Department of Chinese Medicine Information Science, Beijing University of Chinese Medicine;National Institutes for Food and Drug Control;Shenwei Pharmaceutical Group Co., Ltd.;

Email:

DOI: 10.19540/j.cnki.cjcmm.20191219.305

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