中国中药杂志

2017, v.42(11) 2032-2037

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赭曲霉毒素A快速检测方法研究进展及其在中药中的应用前景
Research progress of rapid detection of ochratoxin A and its application prospect in traditional Chinese medicine

胡淑荣;应光耀;胡玉莉;杨世海;杨美华;
HU Shu-rong;YING Guang-yao;HU Yu-li;YANG Shi-hai;YANG Mei-hua;College of Traditional Chinese Medicine,Jilin Agricultural University;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College;

摘要(Abstract):

赭曲霉毒素A(OTA)是一类主要由曲霉属和青霉属等真菌产生的次级代谢产物,具有强烈的肾毒性,致畸、致癌、致突变等作用。研究表明OTA不仅广泛污染于食品饲料和农作物中,近年来在香辛料、甘草等中草药中也被证实广泛存在。鉴于OTA的普遍性和危害性,该文分别综述了可视化试纸条、流式微球技术、电化学传感器、表面增强拉曼光谱等技术在OTA快速检测上的应用,预期为实现OTA检测快速化、操作简单化、仪器小型化的高通量检测研究和应用提供参考。
Ochratoxin A(OTA) is a toxic secondary metabolite mainly produced by Aspergillus and Penicillium species,with strong renal toxicity,teratogenic,carcinogenic,mutagenic effect. Studies have shown that OTA is not only widely contaminated in food and feed crops,but also has been widely contaminated in Chinese herbal medicines such as spices,licorice and so on. In view of OTA' s universality and harmfulness,this paper summarizes the flow visualization test strip,microsphere,electrochemical sensor,surface enhanced Raman spectroscopy technology in OTA rapid detection,which provides reference for the research and application of high throughout detection instrument miniaturization in order to achieve OTA quick detection and simple operation.

关键词(KeyWords): 赭曲霉毒素A;中药;快速检测方法
ochratoxin A;Chinese medicine;rapid detection method

Abstract:

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基金项目(Foundation): 北京市自然科学基金项目(7152101);; 国家自然科学基金面上项目(81274072,81673593,81473346)

作者(Author): 胡淑荣;应光耀;胡玉莉;杨世海;杨美华;
HU Shu-rong;YING Guang-yao;HU Yu-li;YANG Shi-hai;YANG Mei-hua;College of Traditional Chinese Medicine,Jilin Agricultural University;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College;

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