中国中药杂志

2015, v.40(03) 556-559

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藏成药如意珍宝丸对缺血性脑卒中大鼠亚急性期的干预作用
Intervention effect of Tibetan patent medicine Ruyi Zhenbao pills in acute ischemic stroke in rats

刘睿颖;武蔚杰;谭睿;谢彬;钟振东;和静平;陈瑶;康欣丽;
LIU Rui-ying;WU Wei-jie;TAN Rui;XIE Bin;ZHONG Zhen-dong;HE Jing-ping;CHEN Yao;KANG Xin-li;College of Life Science and Engineering,South-West Jao Tong University;Pathological Department,Sichuan Provincial People's Hospital;

摘要(Abstract):

缺血性脑卒中是全球导致死亡及长期致残的主要原因,是由于脑部供血障碍引起脑组织相应区域缺血、低氧,致使脑血管功能障碍出现一系列生化代谢失常、生理功能丧失的疾病,其高致残率给社会、政府和家庭带来了巨大的负担,但目前尚缺少理想的治疗药物。该文在建立大鼠右侧大脑中动脉阻塞模型基础上,从减轻神经元尼氏小体损伤、降低脑水肿及炎症反应、阻止细胞凋亡等方面着手,观察藏成药如意珍宝丸多途径、多方位的干预作用,为探讨该药对缺血性脑卒中的疗效机制奠定重要研究基础。
Ischemic stroke is a primary cause of death and long-term disability all over the world. This disease is resulted from ischemia and hypoxia in brain tissues because of insufficient blood supply and causes a series of physiochemical metabolism disorders and physiological dysfunction. Its high disability ratio has bright huge burdens to society,governments and families. However,there is not efficacious medicine to treat it. In this study,a right middle cerebral artery occlusion was established in rats to observe the multi-path and multi-aspect intervention effects of Tibetan patent medicine Ruyi Zhenbao pills in reducing injuries to Nissl bodies,cerebral edema and inflammatory reactions and preventing cellular apoptosis,in order to lay a foundation for defining its therapeutic mechanism in acute ischemic stroke.

关键词(KeyWords): 如意珍宝丸;脑卒中;大脑中动脉阻塞;尼氏小体;凋亡
Ruyi Zhenbao pills;stroke;cerebral artery occlusion;Nissl bodies;apoptosis

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81274184);; 国家“重大新药创制”科技重大专项(2013ZX09103002-014)

作者(Author): 刘睿颖;武蔚杰;谭睿;谢彬;钟振东;和静平;陈瑶;康欣丽;
LIU Rui-ying;WU Wei-jie;TAN Rui;XIE Bin;ZHONG Zhen-dong;HE Jing-ping;CHEN Yao;KANG Xin-li;College of Life Science and Engineering,South-West Jao Tong University;Pathological Department,Sichuan Provincial People's Hospital;

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