中国中药杂志

2013, v.38(13) 2118-2124

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大血藤中1个新的木脂素类化合物
A new lignan from stems of Sargentodoxa cuneata

袁贤达;高慧敏;陈两绵;张启伟;王智民;
YUAN Xian-da,GAO Hui-min,CHEN Liang-mian,ZHANG Qi-wei,WANG Zhi-min(1.Institute of China Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Beijing 100700,China)

摘要(Abstract):

大血藤来源于木通科植物大血藤Sargentodoxa cuneata的干燥藤茎。该研究通过HPD-100大孔树脂、反复硅胶柱色谱、Sephadex LH-20和制备液相等方法,从采自安徽黄山的大血藤藤茎中分离出20个化合物;根据化合物的理化性质和波谱数据,分别鉴定为(7R,8S)-3,3'-5-三甲氧基-4,9-二羟基-4',7-环氧-5',8-木脂素-7'-烯-9'-酸4-O-β-D-吡喃葡萄糖苷(1),1-O-香草酸-6-O-香草酰基吡喃葡萄糖苷(2),对羟基苯乙醇-6-O-香豆酰吡喃葡萄糖苷(3),枸橼苦素B(4),桂皮苷(5),(-)-异落叶松脂素4'-O-β-D-吡喃葡萄糖苷(6),(-)-异落叶松脂素4-O-β-D-吡喃葡萄糖苷(7),1-O-香草酸-6-(3″,5″-二甲氧基-没食子酰)-β-D-吡喃葡萄糖苷(8),对羟基苯乙醇-6-O-(E)-咖啡酰吡喃葡萄糖苷(9),(-)-丁香树脂醇4'-O-β-D-吡喃葡萄糖苷(10),(-)-丁香树脂醇双葡萄糖苷(11),野菰苷(12),木通苯乙醇苷B(13),4-羟基-3-甲氧基苯乙酮-4-O-α-L-鼠李糖-(1→6)-β-D-吡喃葡萄糖苷(14),4-羟基-3-甲氧基苯乙酮-4-O-β-D-芹糖-(1→6)-β-D-吡喃葡萄糖苷(15),(-)-表儿茶素(16),毛柳苷(17),3,4-二羟基苯乙醇吡喃葡萄糖苷(18),绿原酸(19),原儿茶酸(20),其中化合物1为新化合物,化合物2~7首次从该植物中分离得到。
Sargentodoxae Caulis was prepared from the stems of Sargentodoxa cuneata.Twenty compounds from the the stems of S.cuneata collected in Huangshan Mountain,Anhui province,were isolated and purified by column chromatography on macroporous resin(HPD100),silica gel,Sephadex LH-20 and semi-preparative HPLC.Their structures were elucidated on the basis of physicochemical properties and spectral data analyses as(7R,8S)-3,3′-5-trimethoxy-4,9-dihydroxy-4′,7-expoxy-5′,8-lignan-7′-en-9′-oic acid 4-O-β-D-glucopyranoside(1),1-O-(vanillic acid)-6-O-vanilloyl-β-D-glucopyranoside(2),4-hydroxyphenylethyl-6-O-coumaroyl-β-D-glucopyranoside(3),citrusin B(4),cinnamoside(5),(-)-isolariciresinol 4′-O-β-D-glucopyranoside(6),(-)-isolariciresinol 4-O-β-D-glucopyranoside(7),1-O-(vanillic acid)-6-(3″,5″-dimethoxy-galloyl)-β-D-glucopyranoside(8),4-hydroxyphenyl-ethyl-6-O-(E)-caffeoyl-β-D-glucopyranoside(9),(-)-syringaresinol 4′-O-β-D-glucopyranoside(10),(-)-syringaresinol di-O-β-D-glucopyranoside(11),aegineoside(12),calceolarioside B(13),4-hydroxy-3-methoxy-acetophenone-4-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside(14),4-hydroxy-3-methoxy-acetophenone-4-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside(15),(-)-epicatechin(16),salidroside(17),3,4-dihydroxy-phenyl ethyl-β-D-glucopyranoside(18),chlorogenic acid(19) and protocatechuic acid(20).Compound 1 was a new compound and compounds 2-7 were isolated from this plant for the first time.

关键词(KeyWords): 大血藤;木通科;木脂素;苯乙醇苷
Sargentodoxa cuneata;Lardizabalaceae;lignan;phenylethanoid glucoside

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2012ZX09103201-009,2009ZX09301-005);; 国家药典委员会2015年版《中国药典》任务(2015X8)

作者(Author): 袁贤达;高慧敏;陈两绵;张启伟;王智民;
YUAN Xian-da,GAO Hui-min,CHEN Liang-mian,ZHANG Qi-wei,WANG Zhi-min(1.Institute of China Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Beijing 100700,China)

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