中国中药杂志

2012, v.37(14) 2139-2142

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基于均匀设计的藜芦与细辛配伍毒性研究
Study on toxicity of uniform design-based compatible use of Veratrum nigrum and asarum

王艳丽;王宇光;梁乾德;马增春;肖成荣;谭洪玲;高月;
WANG Yanli1,2,WANG Yuguang2,LIANG Qiande2,MA Zengchun2,XIAO Chengrong2,TAN Hongling2,GAO Yue2(1.PLA General Hospital,Beijing 100853,China; 2.Institute of Radiation Medicine,Academy of Military Medical Science,Beijing 100850,China)

摘要(Abstract):

藜芦与细辛同用,是"十八反"配伍禁忌之一。本实验采用均匀设计结合动物急性毒性实验,以动物死亡数为观测指标,探讨藜芦与细辛配伍的毒性规律。结果显示配伍后的毒性产生于藜芦和细辛的共同作用,且藜芦对配伍毒性的贡献所占权重更大,但配伍后毒性并未随藜芦用量的增加呈绝对上升趋势。
The compatible use of Veratrum nigrum with asarum,is one of the eighteen incompatible pairs.To research the toxic regularity of the compatible use of V.nigrum and asarum,this experiment adopted the uniform design combining with acute toxicity test,with the number of died animals as the observation indicator.The results showed that the toxicity came from the common effect of V.nigrum and asarum,and V.nigrum after the compatible use,and V.nigrum made a greater contribution to the toxicity caused by the compatible use.But the toxicity did not absolutely enhance with the increase in use of V.nigrum.

关键词(KeyWords): 十八反;均匀设计;藜芦;细辛;配伍禁忌;小鼠;急性毒性
eighteen incompatible pairs;uniform design;Veratrum nigrum;asarum;incompatibility;mouse;acute toxicity

Abstract:

Keywords:

基金项目(Foundation): 国家重点基础研究发展计划(973)项目(2011CB505304);; 国家自然科学基金项目(81073149);; 北京市自然科学基金项目(7112110)

作者(Authors): 王艳丽;王宇光;梁乾德;马增春;肖成荣;谭洪玲;高月;
WANG Yanli1,2,WANG Yuguang2,LIANG Qiande2,MA Zengchun2,XIAO Chengrong2,TAN Hongling2,GAO Yue2(1.PLA General Hospital,Beijing 100853,China; 2.Institute of Radiation Medicine,Academy of Military Medical Science,Beijing 100850,China)

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