中国中药杂志

2015, v.40(06) 1023-1026

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基于同源基因功能分化的药用植物活性成分变异机制研究
Different active ingredients of medicinal plant based on function differentiation of homologous gene

袁媛;于军;黄璐琦;王绪敏;
YUAN Yuan;YU Jun;HUANG Lu-qi;WANG Xu-min;State Key Laboratory of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;Key Laboratory of Genome Science and Information,China Academy of Science;

摘要(Abstract):

在中药材质量控制研究领域,药用植物活性成分变异机制研究始终是重点和热点问题。随着高通量测序技术的发展和成本的降低,大量药用植物基因序列克隆为进一步研究基因序列的遗传信息与其所执行的生物学功能奠定了基础,也为从分子生药学角度探索药材活性成分变异及其质量控制提供了有力条件。该文详细介绍了同源基因、基因重复的概念和分类,并重点展望了重复基因功能分化在药用植物活性成分变异分子机制研究中的作用,旨在为药材质量控制基础研究提供新的思路。
In the research field of quality control in Chinese medicinal materials,variation in active ingredients of medicinal plant is always the key and hot issues. With the development of high-throughput sequencing technologies and reducing cost,a large numbers of genes from medicinal plant were cloning and provide a solid foundation for further research of gene structure and its biological function,and also provides conditions for explore active ingredient variation and its quality control from the perspective of molecular pharmacognosy. This paper introduces the concept of homologous gene,gene duplication and classification. We prospect the function of duplicated genes in the role of molecular mechanism research about variation in active ingredients,aiming at providing a new way for medicinal materials quality control.

关键词(KeyWords): 基因复制;功能分化;活性成分;变异
gene replication;functional differentiation;active ingredients;variation

Abstract:

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基金项目(Foundation): 国家自然科学基金项目(81373959);; 国家杰出青年科学基金项目(81325023);; 国家高技术研究发展计划(863)项目(SS2014AA022201)

作者(Author): 袁媛;于军;黄璐琦;王绪敏;
YUAN Yuan;YU Jun;HUANG Lu-qi;WANG Xu-min;State Key Laboratory of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;Key Laboratory of Genome Science and Information,China Academy of Science;

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