中国中药杂志

2003, (09)

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

黄芪、当归配伍后促鸡胚绒毛尿囊膜血管生成的药效比较研究
Comparative Study on Angiogenesis Effect of Astragalus membranaceus and Angelica sinensis in Chick Embryo Choriollantoic Membrane

雷燕,王军辉,陈可冀
LEI Yan, WANG Jun-hui, CHEN Ke-ji (Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Trad itional Chinese Medicine, Beijing 100091,China)

摘要(Abstract):

目的 :探讨黄芪、当归不同配伍对鸡胚绒毛尿囊膜 (chorioallantoicmembrane ,CAM )新生血管生成的影响。方法 :制备CAM模型 ,观察应用黄芪与当归 5∶1配比的含药血清后CAM血管生成的情况。结果 :黄芪与当归合用后 ,在血管生成表现以及血管计数方面 ,均明显优于生理盐水对照组及其他配比组。结论 :黄芪与当归按 5∶1配伍具有较好的促进CAM新生血管生成的作用 ,表明当归补血汤原方配比为最佳组合 ,提示中医自古倡导的方剂配伍原则具有一定的科学内涵
Objective: To explore the angiogenesis eff ec t of Astragalus membranaceus and Angelica sinensis with different ratio in chick embryo chorioallantoic membrane (CAM). Method: Ch icken CAM model was adopted. The rat blood serum containing different ratio of Astragalus membranaceus and Angelica sinensis was put daily into 3-day chick embryo. CAMs and CAM angiogenesis were observed at 72 h after incubation . Result: Better effects were obtained in the formation of capillary and the count of blood vessel in groups treated by Astragalus memhr anaceus and Angelica sinensis in the ratio of five to one , compared with the NS control group and the other ratio groups of Astragalus memhranaceus a nd Angelica sinensis. Conclusion: Astragalus memhran aceus and Angelica sinensis in 5∶1 ratio have certain promotive effect on the formation of capillary. The Danggui Buxue Decoction has the best ratio.

关键词(KeyWords): 鸡胚绒毛尿囊膜;血管新生;当归补血汤;黄芪;当归
chorioallantoic membrane(CAM); angiogenesi s; Danggui Buxue Decoction;Astragalus membranaceus; Angelica sinensis

Abstract:

Keywords:

基金项目(Foundation): 国家重大基础研究“973”课题 ( 2 0 0 0 0570 1 0 )

作者(Author): 雷燕,王军辉,陈可冀
LEI Yan, WANG Jun-hui, CHEN Ke-ji (Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Trad itional Chinese Medicine, Beijing 100091,China)

Email:

DOI:

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享