中国中药杂志

2008, (01) 105-107

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温敏凝胶释药模式及机制研究进展
Advances in research on drug release mechanisms and modes of thermosensitive gel

姜玲海;冯怡;沈岚;徐德生;
JIANG Ling-hai1,FENG Yi1,SHEN Lan1,XU De-sheng2(1.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;2.Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

摘要(Abstract):

温敏凝胶因具临界相转变温度而被作为能达到定点、定时、定量释药目的药物控释体系的载体之一成为近年来研究的热点。随着温敏凝胶研究和应用的不断深入,其释药模式及机制被不断提出和发现,不同释药特征的释药模型也相继建立。温敏凝胶释药模型、模式及机制的研究透彻将使温敏凝胶在医药、生物等领域得到更好的应用。
Thermosensitive gel with the property of LCST(Lower Critical Solution Temperature) was studied as a hot spot these years for it can be used as one supportor of drug controlled release system which can release drug at right point,right time and right quantity.With further reseaches and applications of thermosensitive gel,the modes and mechanisms of it were discovered and poited out,drug release models were also established step by step.Resesrches on drug release mechanisms and modes of thermosensitive gel will make it applied better in fields of medicine and biology.

关键词(KeyWords): 药物控释体系;温敏凝胶;释药模式;释药机制
drug controlled release system;thermosensitive gel;drug release mode;drug release machanism

Abstract:

Keywords:

基金项目(Foundation): 上海市科委项目(03DZ19521)

作者(Authors): 姜玲海;冯怡;沈岚;徐德生;
JIANG Ling-hai1,FENG Yi1,SHEN Lan1,XU De-sheng2(1.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;2.Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

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