中国中药杂志

2017, v.42(18) 3465-3468

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重楼同属植物南重楼的药理研究
Pharmacodynamics study on Paris vietnamensis

李洪梅;孙建辉;康利平;霍海如;李小芹;黄圆圆;陈敏;黄璐琦;
LI Hong-mei;SUN Jian-hui;KANG Li-ping;HUO Hai-ru;LI Xiao-qin;HUANG Yuan-yuan;CHEN Min;HUANG Lu-qi;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;State Key Laboratory of Dao-di Herbs,National Resource Center For Materia Medica,China Academy of Chinese Medical Sciences;

摘要(Abstract):

重楼为常用中药材,目前资源紧缺,除法定品种云南重楼和七叶一枝花外,同属多种近缘植物均被收购作为重楼入药。该研究比较了重楼同属植物南重楼和药典收载的云南重楼、七叶一枝花在抗炎、止血、改善血流变方面的药理活性,以其扩大重楼药用资源范围,保护重楼野生资源,满足市场需求。研究表明云南重楼、七叶一枝花、南重楼具有抗炎、止血和改善血流变作用,可明显抑制角叉菜胶致足肿胀,缩短小鼠出血时间和凝血时间,明显降低大鼠急性血瘀模型各切变率下的全血黏度;云南重楼、南重楼可明显抑制小鼠腹腔毛细血管通透性的增高。
Paris is commonly used in traditional Chinese medicine and its resource is in shortage,a variety of related plants are acquired as Paris. This study compared pharmacological activity in anti-inflammatory and hemostatic and blood rheology of P. vietnamensis with pharmacopoeial Paridis Rhizoma to expand its range of Paris medicinal resources and protect wild resources of Paris and meet market demand. The experimental study showed that P. vietnamensis and P. polyphylla var. yunnanensis and P. polyphylla var. chinensis had anti-inflammatory and hemostatic effect and improved blood rheolog. They can significantly inhibit rat foot swelling induced by carrageenan and short the bleeding time and clotting time and reduce the blood viscosity in rats with acute blood stasis model, P. vietnamensis and P. polyphylla var. yunnanensis can inhibit mice capillary permeability induced by acetic acid.

关键词(KeyWords): 南重楼;抗炎;止血;改善血流变
Paris vietnamensis;anti-inflammatory;hemostatic effect;improve blood rheolog

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2014ZX09301306-001)

作者(Author): 李洪梅;孙建辉;康利平;霍海如;李小芹;黄圆圆;陈敏;黄璐琦;
LI Hong-mei;SUN Jian-hui;KANG Li-ping;HUO Hai-ru;LI Xiao-qin;HUANG Yuan-yuan;CHEN Min;HUANG Lu-qi;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;State Key Laboratory of Dao-di Herbs,National Resource Center For Materia Medica,China Academy of Chinese Medical Sciences;

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DOI: 10.19540/j.cnki.cjcmm.20170814.002

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