中国中药杂志

2020, v.45(24) 5866-5876

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慢性疼痛动物模型研究进展及在中医药研究中的应用
Research progress on animal models of chronic pain and its application in traditional Chinese medicine research

代倩倩;李心怡;夏桂阳;夏欢;卫晓红;商洪才;林生;田贵华;
DAI Qian-qian;LI Xin-yi;XIA Gui-yang;XIA Huan;WEI Xiao-hong;SHANG Hong-cai;LIN Sheng;TIAN Gui-hua;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine;

摘要(Abstract):

慢性疼痛分类复杂,发病机制尚不明确,目前治疗措施有限且进展缓慢。中医药在治疗慢性疼痛方面具有一定优势,其作用机制有待深入探讨。理想的动物模型有助于还原慢性疼痛发生发展的关键机制,对于新靶点的发现、新疗法的开发和中医药镇痛机制的研究至关重要。近年来,国内外众多学者为探明慢性疼痛的发病机制及中医药作用机制做了大量研究,并取得一些成果。该研究在此基础上总结了慢性疼痛实验动物的选择和动物模型常用的评价方法,按照最新版国际疾病分类梳理了慢性原发性疼痛、慢性癌症相关疼痛等七大类慢性疼痛常用的动物模型制备方法、评价指标及其各自的优缺点,并介绍了中医药研究中常用的慢性疼痛动物模型,为今后开展相关实验时有针对性地选择动物模型提供参考。
The classification of chronic pain is complex and its pathogenesis is not clear, which led to the limited progress of treatment measures.Traditional Chinese medicine(TCM) has certain advantages in the treatment of chronic pain, and its mechanism needs further exploration. The ideal animal model is helpful to elucidate the key mechanism of the occurrence and development of chronic pain and play an important role in the discovery of new drug targets, the development of new therapies and the research on the analgesic mechanism of TCM.In recent years, many scholars at home and abroad have done a lot of research to explore the pathogenesis of chronic pain and the mechanism of TCM, which have achieved some results. On this basis, this study summarizes the selection of experimental animals for chronic pain and the commonly evaluation methods of animal models. According to the latest international classification of diseases, this review organizes the induced methods, evaluation indicators, advantages and disadvantages of seven kinds of chronic pain animal models, such as chronic primary pain, chronic cancer-related pain and so on. Next, this review introduces the chronic pain animal models commonly used in TCM research, in order to provide guidance for the targeted selection of animal models when carrying out relevant experiments in the future.

关键词(KeyWords): 慢性疼痛;动物模型;评价方法;中医药;研究进展
chronic pain;animal models;evaluation methods;traditional Chinese medicine;research progress

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81973623,81674050)

作者(Author): 代倩倩;李心怡;夏桂阳;夏欢;卫晓红;商洪才;林生;田贵华;
DAI Qian-qian;LI Xin-yi;XIA Gui-yang;XIA Huan;WEI Xiao-hong;SHANG Hong-cai;LIN Sheng;TIAN Gui-hua;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine;

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DOI: 10.19540/j.cnki.cjcmm.20200924.201

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