中国中药杂志

2017, v.42(18) 3461-3464

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重楼同属植物长柱重楼与药用重楼的药效学对比研究
Comparative pharmacodynamics study on Paris forrestii and pharmacopoeial Paridis Rhizoma

李洪梅;孙建辉;康利平;霍海如;李小芹;黄圆圆;陈敏;黄璐琦;
LI Hong-mei;SUN Jian-hui;KANG Li-ping;HUO Hai-ru;LI Xiao-qin;HUANG Yuan-yuan;CHEN Min;HUANG Lu-qi;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;State Key Laboratory of Dao-di Herbs,National Resource Center for Materia Medica,China Academy of Chinese Medical Sciences;

摘要(Abstract):

重楼为多种中成药的原料,由于市场需求量大幅增长,野生重楼资源日益减少,人工栽培生长缓慢,导致重楼资源紧缺。该研究比较了重楼同属植物长柱重楼和药典收载的云南重楼、七叶一枝花在镇痛、抗炎、止血方面的药理活性,以其扩大重楼药用资源范围,保护重楼野生资源,满足市场需求。该实验研究表明长柱重楼和云南重楼、七叶一枝花均具有镇痛、抗炎、止血作用,可明显降低醋酸致小鼠扭体次数,抑制角叉菜胶致大鼠足肿胀和醋酸致小鼠腹腔毛细血管通透性增高,缩短出血时间和凝血时间,且长柱重楼与云南重楼、七叶一枝花的镇痛、抗炎、止血作用相当。
Paris is a raw material of a variety of Chinese medicines,which has become deficient in resource due to market demand substantial growth and wild Paris resources reducing increasingly and the artificial cultivation slow growth. This study compared pharmacological activity in analgesia and anti-inflammatory and hemostasis effects of P. forrestii with pharmacopoeial Paridis Rhizoma to expand its range of Paris medicinal resources and protect wild resources of Paris and meet market demand. The experimental study showed that P. forrestii and P. polyphylla var. yunnanensis and P. polyphylla var. chinensis had analgesic,anti-inflammatory and hemostatic effects. They can significantly reduce the number of writhing and inhibit rat foot swelling induced by carrageenan and mice capillary permeability induced by acetic acid and short the bleeding time and clotting time. Their function is equivalent.

关键词(KeyWords): 长柱重楼;镇痛;抗炎;止血
Paris forrestii;analgesia;anti-inflammatory;hemostatic effect

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2014ZX09301306-001)

作者(Author): 李洪梅;孙建辉;康利平;霍海如;李小芹;黄圆圆;陈敏;黄璐琦;
LI Hong-mei;SUN Jian-hui;KANG Li-ping;HUO Hai-ru;LI Xiao-qin;HUANG Yuan-yuan;CHEN Min;HUANG Lu-qi;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;State Key Laboratory of Dao-di Herbs,National Resource Center for Materia Medica,China Academy of Chinese Medical Sciences;

Email:

DOI: 10.19540/j.cnki.cjcmm.20170814.001

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