中国中药杂志

2015, v.40(11) 2123-2127

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微波技术在桂枝茯苓胶囊提取过程中的应用
Application of microwave technology in extraction process of Guizhi Fuling capsule

王正宽;周茆;刘圆;毕宇安;王振中;萧伟;
WANG Zheng-kuan;ZHOU Mao;LIU Yuan;BI Yu-an;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Parmaceutical Co. ,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

摘要(Abstract):

该文在中试规模下考察微波技术在桂枝茯苓胶囊提取过程中的最佳条件,首先,对各因素进行单因素试验考察,确定各因素大致的影响趋势及范围;其次,以L9(34)正交试验进行优化,检测药液中没食子酸、芍药苷、苯甲酸、肉桂酸、苯甲酰芍药苷、苦杏仁苷的含量,分别计算其提取率并进行综合评价,以其作为提取效果的评判依据。微波提取桂枝茯苓胶囊的最佳工艺为按液固比6∶1加入饮用水,设定微波功率6 k W,提取20 min,提取3次。该工艺经3批放大试验验证,结果稳定,且相比常规煎煮提取具有节能、省时、高效的优势。以上结果显示该优化工艺提取效率高,且稳定可行。
In this paper,optimization of the conditions of microwave technique in extraction process of Guizhi Fuling capsule in the condition of a pilot scale was carried out. First of all,through the single factor experiment investigation of various factors,the overall impact tendency and range of each factor were determined. Secondly,L9(34) orthogonal test optimization was used,and the contents of gallic acid in liquid,paeoniflorin,benzoic acid,cinnamic acid,benzoyl paeoniflorin,amygdalin of the liquid medicine were detected.The extraction rate and comprehensive evaluation were calculated with the extraction effect,as the judgment basis. Theoptimum extraction process of Guizhi Fuling capsule by microwave technology was as follows: the ratio of liquid to solid was 6∶ 1 added to drinking water,the microwave power was 6 k W,extraction time was 20 min for 3 times. The process of the three batch of amplification through verification,the results are stable,and compared with conventional water extraction has the advantages of energy saving,time saving,high efficiency advantages. The above results show the optimum extracting technology of high efficiency,stable and feasible.

关键词(KeyWords): 没食子酸;芍药苷;苯甲酸;肉桂酸;苯甲酰芍药苷;苦杏仁苷;单因素试验;正交试验;微波提取
gallic acid;paeoniflorin;benzoic acid;cinnamic acid;benzoyl paeoniflorin;amygdalin;single factor experiment;orthogonal test;microwave extraction

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 王正宽;周茆;刘圆;毕宇安;王振中;萧伟;
WANG Zheng-kuan;ZHOU Mao;LIU Yuan;BI Yu-an;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Parmaceutical Co. ,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

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