中国中药杂志

2019, v.44(10) 2124-2130

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基于网络药理学探索生化汤治疗小腹痛的药理机制
Pharmacological mechanism of Shenghua Decoction in treatment of abdominal pain based on network pharmacology

王煊;于河;白辰;徐竞男;甄建华;谷晓红;
WANG Xuan;YU He;BAI Chen;XU Jing-nan;ZHEN Jian-hua;GU Xiao-hong;School of Chinese Materia Medica,Beijing University of Chinese Medicine;

摘要(Abstract):

《傅青主女科》中所记载的生化汤为产后常用方,广泛应用于产后及妇科诸症,但其治疗小腹痛的作用机制尚不明确。该文应用网络药理学,探索生化汤治疗小腹疼痛的作用机制,为临床更好的使用生化汤提供数据支持。在SymMap中分别检索小腹痛和生化汤药物的靶标,运用String和Cytoscape进行富集分析,构建症-药-靶标生物网络。结果显示,生化汤中含有靶标400个,其中11个与小腹痛的疾病基因重合;经String分析,得到基因间互作关系18个;经模块化处理后,得到含有6个基因的1个模块;经String富集分析,得到biological process富集结果 170条、molecular function富集结果 2条、KEGG pathways富集结果 30条。生化汤可能通过神经-内分泌-免疫、代谢等多方面参与小腹痛的治疗过程,其机制为通过加快子宫内组织细胞的修复增长,改善微循环,促进子宫内膜细胞更新及炎症消退,加速子宫复旧,同时调节自身免疫力,应用信号通路在部分天然免疫细胞抗感染过程中的功能和调控作用,补益正气,引邪外达,而达到治疗小腹痛的效果。
The Shenghua Decoction recorded in Fu Qing Zhu's Gynaecology,is a commonly used postpartum prescription,widely used in treating postpartum and gynecological diseases. However,its mechanism of action in treating lower abdominal pain remains unclear. In this paper,network pharmacology was used to explore the mechanism of Shenghua Decoction in the treatment of lower abdomen pain,so as to provide data support for better clinical application of Shenghua Decoction. The drug targets of lower abdominal pain and Shenghua Decoction were retrieved in SymMap. String and Cytoscape were adopted for enrichment analysis to construct the disease-drug-target biological network. Relevant gene search results showed that there were 400 targets in Shenghua Decoction,11 of which coincided with the disease genes of lower abdomen pain. In String analysis,18 gene interactions were obtained. Gene modularizationbased analysis results indicated that one module containing six genes was obtained after modularization processing. Furthermore,there were 170 enrichment results of biological process,2 enrichment results of molecular function and 30 enrichment results of KEGG pathways in String enrichment analysis. Shenghua Decoction may play a role in treating lower abdomen pain through neuro-endocrine-immune,metabolism and other means. Its mechanism may be achieved by accelerating the repair and growth of endometrial tissue cells,improving microcirculation,promoting endometrial cell renewal and inflammation subsidence,and accelerating uterine involution; at the same time,it can regulate the autoimmunity,regulate and control the function of some natural immune cells in the process of antiinfection by using signaling pathway,supplement the vital energy,and induce elimination of pathogens from the body,thereby achieving the effect of treating lower abdomen pain.

关键词(KeyWords): 生化汤;小腹痛;网络药理学;作用机制
Shenghua Decoction;lower abdominal pain;network pharmacology;mechanism

Abstract:

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基金项目(Foundation): 国家重点研发计划项目(2018YFC1704101)

作者(Author): 王煊;于河;白辰;徐竞男;甄建华;谷晓红;
WANG Xuan;YU He;BAI Chen;XU Jing-nan;ZHEN Jian-hua;GU Xiao-hong;School of Chinese Materia Medica,Beijing University of Chinese Medicine;

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