中国中药杂志

2018, v.43(03) 520-526

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中药炮制用辅料姜汁的冻干工艺优化及冻干粉稳定性考察
Freeze drying process optimization of ginger juice-adjuvant for Chinese materia medica processing and stability of freeze-dried ginger juice powder

杨春雨;郭凤倩;藏琛;曹晖;张保献;
YANG Chun-yu;GUO Feng-qian;ZANG Chen;CAO Hui;ZHANG Bao-xian;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;School of Pharmacy,Ji'nan University;

摘要(Abstract):

姜汁是常用的中药炮制用辅料,用于多种中药饮片的炮制。姜汁的原料和制备工艺决定了姜汁难以长时间保存,在用于炮制时无法根据有效成分含量决定用量;不同来源姜汁用于中药饮片炮制难以实现一致的炮制效果。该文以前期姜汁干燥研究为基础,对姜汁在不同搁板温度和真空度条件下的冷冻干燥进行了研究,确定了姜汁冷冻干燥的优化条件;建立了姜汁和复溶姜汁中6-姜酚,8-姜酚,10-姜酚,6-姜烯酚含量测定方法;对姜汁在冷冻干燥前后及30 d内的保存期内6-姜酚,8-姜酚,10-姜酚,6-姜烯酚含量、挥发油含量及总酚含量的变化进行了研究。结果表明,工艺优化后姜汁冻干时间大大缩短;姜汁冻干前后成分基本一致,姜辣素、总酚含量无显著性变化,挥发油含量有显著性下降(P<0.05);30 d内,姜辣素、总酚、挥发油含量总体呈下降趋势。该研究初步证明了中药炮制用辅料姜汁冻干的可行性。
Ginger juice,a commonly used adjuvant for Chinese materia medica,is applied in processing of multiple Chinese herbal decoction pieces. Because of the raw materials and preparation process of ginger juice,it is difficult to be preserved for a long time,and the dosage of ginger juice in the processing can not be determined base on its content of main compositions. Ginger juice from different sources is hard to achieve consistent effect during the processing of traditional Chinese herbal decoction pieces. Based on the previous studies,the freeze drying of ginger juice under different shelf temperatures and vacuum degrees were studied,and the optimized freeze drying condition of ginger juice was determined. The content determination method for 6-gingerol,8-gingerol,10-gingerol and6-shagaol in ginger juice and redissolved ginger juice was established. The content changes of 6-gingerol,8-gingerol,10-gingerol,6-gingerol,6-shagaol,volatile oil and total phenol were studied through the drying process and 30 days preservation period. The results showed that the freeze drying time of ginger juice was shortened after process optimization; the compositions basically remained unchanged after freeze drying,and there was no significant changes in the total phenol content and gingerol content,but the volatile oil content was significantly decreased( P < 0. 05). Within 30 days,the contents of gingerol,total phenol,and volatile oil were on the decline as a whole. This study has preliminarily proved the feasibility of freeze-drying process of ginger juice as an adjuvant for Chinese medicine processing.

关键词(KeyWords): 姜汁;中药炮制用辅料;现代化;冷冻干燥;中药炮制
ginger juice;adjuvant for Chinese medicine processing;modernization;freeze drying;Chinese medicine processing

Abstract:

Keywords:

基金项目(Foundation): 国家药典委员会项目(2017-3)

作者(Author): 杨春雨;郭凤倩;藏琛;曹晖;张保献;
YANG Chun-yu;GUO Feng-qian;ZANG Chen;CAO Hui;ZHANG Bao-xian;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;School of Pharmacy,Ji'nan University;

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DOI: 10.19540/j.cnki.cjcmm.20171208.008

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