中国中药杂志

2021, v.46(20) 5210-5217

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NLRP3炎症小体介导的心肌细胞焦亡及中药干预研究进展
Advances in research on cardiomyocyte pyroptosis mediated by NLRP3 inflammasome and traditional Chinese medicine intervention

葛子硕;徐志猛;李萍;
GE Zi-shuo;XU Zhi-meng;LI Ping;State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University;

摘要(Abstract):

细胞焦亡作为一种促炎的程序性细胞死亡方式,其在心脏炎症反应发生发展过程中的作用是当下的研究热点。核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体的激活是诱发由含半胱氨酸的天冬氨酸蛋白酶1(caspase-1)介导的细胞焦亡的重要机制。现有研究发现心肌细胞焦亡参与了多种心血管疾病的疾病进程,其中NLRP3炎症小体介导的心肌细胞焦亡研究最为广泛。同时,干预NLRP3炎症小体的激活与心肌细胞焦亡可作为减轻心肌损伤的有效手段,也是许多中药发挥心脏保护作用的重要环节。因此,该文综述了NLRP3炎症小体介导的心肌细胞焦亡的研究进展并提出中药干预该激活过程的研究方向。
Pyroptosis is a pro-inflammatory programmed cell death, and its role in cardiac inflammatory response has become a hot topic. The activation of nucleotide binding oligomerization domain like receptor protein 3(NLRP3) inflammasome is an important mechanism for pyroptosis induced by cysteinyl aspartate specific proteinase 1(caspase-1). The existing studies have shown that cardiomyocyte pyroptosis participates in the pathogenesis of different cardiovascular diseases and the NLRP3 inflammasome-mediated cardiomyocyte pyroptosis has been most widely studied. Also, the intervention in NLRP3 inflammasome activation and cardiomyocyte pyroptosis contributes to ameliorating myocardial injury, which may be the main mechanism of many traditional Chinese medicines in exerting the cardio-protective effects. Therefore, this paper reviewed the studies on cardiomyocyte pyroptosis mediated by NLRP3 inflammasome and put forward the importance of exploring traditional Chinese medicine intervention in the activation of NLRP3 inflammasome.

关键词(KeyWords): NLRP3炎症小体;心肌细胞焦亡;中药
nucleotide binding oligomerization domain like receptor protein 3(NLRP3) inflammasome;cardiomyocyte pyroptosis;traditional Chinese medicine

Abstract:

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基金项目(Foundation): 国家重点研发计划项目(2018YFC1707300)

作者(Author): 葛子硕;徐志猛;李萍;
GE Zi-shuo;XU Zhi-meng;LI Ping;State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University;

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