中国中药杂志

2022, v.47(18) 4863-4876

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滇重楼中甾体皂苷类化学成分及其微生物转化研究进展
Research progress of steroidal saponins in Paris polyphylla var. yunnanensis and their microbial transformation

周迪;潘齐冬;晏秀祥;高路;杨立新;
ZHOU Di;PAN Qi-dong;YAN Xiu-xiang;GAO Lu;YANG Li-xin;School of Ethnic Medicine, Yunnan Minzu University;Kunming Institute of Botany, Chinese Academy of Sciences;

摘要(Abstract):

甾体皂苷类化学成分是滇重楼中数量和含量最多的一类重要天然有机化合物,具有较好的生物活性。以甾体皂苷类化学成分为底物,利用微生物转化来获取大量结构新颖、活性优良的甾体皂苷,能为甾体药物的研发提供功能性的先导化合物。该文系统综述了滇重楼中甾体皂苷类化学成分及相关化学成分微生物转化研究进展,发现滇重楼中共有甾体皂苷类化学成分112个,其中,有8个甾体皂苷被作为底物,通过25种微生物参与了35个转化反应,转化率最高可达95%,使用频率最高的底物是薯蓣皂苷元,并对转化反应中使用的菌株、培养基、反应条件、转化率以及转化反应特征变化和转化产物的生物活性进行了归纳总结,以期为深入研究滇重楼甾体皂苷类化学成分的微生物转化提供参考。
Steroidal saponins, important natural organic compounds in Paris polyphylla var. yunnanensis, have good biological activity. Structural modification of steroidal saponins by microbial transformation could produce a large number of products with novel structures and excellent bioactivity, which can provide functional compounds for the research and development of steroidal drugs. This study summarized the research progress in steroidal saponins and their microbial transformation in P. polyphylla var. yunnanensis. P. polyphylla var. yunnanensis contains 112 steroidal saponins, 8 of which are used as substrates in 35 transformation reactions by 25 microbial species, with the highest transformation rate of 95%. Diosgenin is the most frequently used substrate. Furthermore, the strains, culture medium, reaction conditions, transformation rate, transformation reaction characteristics, and biological activities of the transformed products were summarized. This review may provide reference for the further research on microbial transformation of steroidal saponins in P. polyphylla var. yunnanensis.

关键词(KeyWords): 滇重楼;甾体皂苷;微生物转化;真菌和细菌;进展
Paris polyphylla var.yunnanensis;steroidal saponins;microbial transformation;fungi and bacteria;progress

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(31970357)

作者(Authors): 周迪;潘齐冬;晏秀祥;高路;杨立新;
ZHOU Di;PAN Qi-dong;YAN Xiu-xiang;GAO Lu;YANG Li-xin;School of Ethnic Medicine, Yunnan Minzu University;Kunming Institute of Botany, Chinese Academy of Sciences;

DOI: 10.19540/j.cnki.cjcmm.20220506.204

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