中国中药杂志

2021, v.46(15) 3780-3788

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挥发性成分在临方制剂中的量值传递研究——以薄荷为例
Quality value transmitting of volatile components in personalized preparations:a case study of Menthae Haplocalycis Herba

李益萍;洪燕龙;沈岚;冯怡;林晓;王优杰;
LI Yi-ping;HONG Yan-long;SHEN Lan;FENG Yi;LIN Xiao;WANG You-jie;College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine;Health Service Collaborative Innovation Center of Shanghai Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education,Shanghai University of Traditional Chinese Medicine;

摘要(Abstract):

基于特征图谱与3种挥发性成分量值传递关系的结合,考察薄荷挥发性成分在临方制剂各涉热环节中的变化规律,明确含挥发性成分的中药在临方制剂应用的关键工艺控制点。采用气相色谱法,建立薄荷挥发性成分的特征图谱,并对薄荷中的3种挥发性有效成分薄荷酮、薄荷醇和胡椒酮进行含量测定。比较了薄荷挥发性成分在粉碎、提取、浓缩和制剂产品干燥工艺过程中成分保留率及特征峰的变化规律。结果表明,薄荷挥发性成分在各个环节中都有所损失,粉碎环节损失率相对较小,且没有成分峰的缺失,但在提取和浓缩环节中薄荷酮、薄荷醇和胡椒酮的损失率较高,存在部分成分峰的缺失以及新增成分峰。此外,在制剂干燥环节,以川芎茶调方为模型处方,比较了薄荷以生粉入药用于制备颗粒或丸剂时其挥发性成分的变化情况,结果为丸剂优于颗粒剂。该研究明确了影响薄荷挥发性成分保留率的关键在于提取和浓缩环节,同时发现制剂的包裹作用可减少薄荷生粉挥发性成分的损失,为含有挥发性成分的药材在临方制剂中的应用提供了参考。
Considering the characteristic chromatograms and quality value transmitting of three volatile components, this study investigated the changes in volatile components of Menthae Haplocalycis Herba in each heating process of personalized preparations and identified the critical control points for the application of volatile components from traditional Chinese medicine in such preparations. The characteristic chromatograms of volatile components in Menthae Haplocalycis Herba were established by gas chromatography, followed by the quantitative determination of three volatile components menthone, menthol, and piperitone and the comparison of retention rates of volatile components during the crushing, extraction, concentration and drying of preparation products and their change rules in characteristic peaks. The results showed that the volatile components of Menthae Haplocalycis Herba were reduced in each process. The loss rate was low in the crushing process when the volatile component peaks were present, but high in the extraction and concentration processes, manifested as the absence of partial component peaks and the presence of new component peaks. The changes in volatile components of Chuanxiong Chatiao Granule in the drying process were compared with those in Chuanxiong Chatiao Pill, both of which were prepared from the raw Menthae Haplocalycis Herba powder, and the findings demonstrated that Chuanxiong Chatiao Pill was superior to Chuanxiong Chatiao Granule. This study confirmed that the retention rates of volatile components in Menthae Haplocalycis Herba were mostly affected by the extraction and concentration processes, and the packing of preparations helped to reduce the loss of volatile components in Menthae Haplocalycis Herba powder, which has provided reference for the application of Chinese medicinal materials containing volatile components in the personalized preparations.

关键词(KeyWords): 薄荷;临方制剂;挥发性成分;气相;量值传递
Menthae Haplocalycis Herba;personalized preparations;volatile components;gas chromatography;quality value transmitting

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81973490);; 上海市自然科学基金项目(18ZR1439800,18ZR1436600,19ZR1457700,20ZR1458400);; 上海市“科技创新行动计划”技术标准项目(20DZ2200900);; 上海市卫生和计划生育委员会中医药事业发展三年行动计划项目[ZY(2018-2020)-CCCX-2001-03];; 2021年度上海市协同创新中心建设项目(2021科技01-01-30)

作者(Authors): 李益萍;洪燕龙;沈岚;冯怡;林晓;王优杰;
LI Yi-ping;HONG Yan-long;SHEN Lan;FENG Yi;LIN Xiao;WANG You-jie;College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine;Health Service Collaborative Innovation Center of Shanghai Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education,Shanghai University of Traditional Chinese Medicine;

DOI: 10.19540/j.cnki.cjcmm.20210525.303

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