中国中药杂志

1995, (12)

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瑞香素及其铜(Ⅱ)、锌(Ⅱ)配合物对超氧自由基的清除作用
Scavenging Effects of Daphnetin and Its Cu, Zn Complexes on superoxide Radical

胡道道,房喻,崔亚丽,孙作民
Hu Daedao; Fang Yu ;Cui Yali ;and Sun Zuomin(Chemistry Department of Shaanxi Normal University ,Xi'an 710062 )

摘要(Abstract):

以健康人血红细胞及细胞膜为实验材料,利用核黄素-蛋氨酸光照体系产生O_2,考察了瑞香素及其铜(Ⅱ)、锌(Ⅱ)配合物对o_2的清除作用,以铜(Ⅱ)配合物活性最高。SOD、瑞香素及其铜(Ⅱ)、锌(Ⅱ)配合物对膜中过氧化脂质的产生均有一定的抑制作用。其中以SOD活性最高。
The scavenging effects of daphnetin (D) and its Cu ,Zn complexes on superoxide radical (O) gener-ated through the photooxidation of riboflavin were studied with human red blood cells (RBC) and RBC membrane asexperimental material. The Cu(Ⅱ) complex showed the highest activity. SOD, D and its Cu ( Ⅱ) ,Zn ( Ⅱ ) complexeswese found to have inhibitory effect on the production of lipid peroxide in the membrane ,SOD being the best amongthem.

关键词(KeyWords): 瑞香素,配合物,超氧自由基,脂质过氧化
daphnetin; complex; superoxide radical; lipid peroxidation

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作者(Authors): 胡道道,房喻,崔亚丽,孙作民
Hu Daedao; Fang Yu ;Cui Yali ;and Sun Zuomin(Chemistry Department of Shaanxi Normal University ,Xi'an 710062 )

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