中国中药杂志

2022, v.47(18) 4854-4862

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中药“醋制入肝”炮制理论的研究进展与探讨
Processing theory of "leading vinegar-processing Chinese medicine into liver"

张倩;薛蓉;徐瑞杰;何天雨;苏联麟;张伟;李林;季德;毛春芹;陆兔林;
ZHANG Qian;XUE Rong;XU Rui-jie;HE Tian-yu;SU Lian-lin;ZHANG Wei;LI Lin;JI De;MAO Chun-qin;LU Tu-lin;School of Pharmacy, Nanjing University of Chinese Medicine;

摘要(Abstract):

中药炮制是中医临床辨证施治组方遣药的特色,“醋制入肝”是最具代表性的传统中药炮制理论之一,该理论指导下的中药醋制是体现中药炮制“增效减毒”的典型代表。该文通过考证“醋制入肝”传统理论,对其内涵展开探讨,结合中药“醋制入肝”的研究现状,分别从物质基础、药效研究及中药归经等方面探索醋制入肝的效应机制,并对目前研究中存在问题进行分析,对醋制中药解毒增效的现代研究进行综述,深入探索“醋制入肝”传统炮制理论的科学内涵。同时提出基于中药质量标志物、生物靶向和临床组方疗效的“醋制入肝”效应机制研究的趋势和思路,为进一步开展“醋制入肝”研究提供参考,为中医临床合理选用炮制品提供科学依据。
The processing of Chinese medicine is a unique and dialectical treatment of traditional Chinese medicine in clinic.The processing theory of "leading vinegar-processing Chinese medicine into liver" is one of the traditional processing theories of Chinese medicine.The vinegar-processing Chinese medicine under the guidance of the processing theory typically reflects the characteristics of "reducing toxicity and enhancing efficacy" of the processing of Chinese medicine.This paper traced the origin and discussed the connotation of the traditional theory of "leading vinegar-processing Chinese medicine into liver".Combined with the research status of "lea-ding vinegar-processing Chinese medicine into liver", this paper explored the mechanism of "leading vinegar-processing Chinese medicine into liver" from the aspects of material basis, medicine effect, and traditional Chinese medicine(TCM) meridian, and analyzed the existing problems in the current research.This paper reviewed the modern study on reducing toxicity and enhancing efficacy of vinegar-processing Chinese medicine, and deeply explored the scientific connotation of the traditional processing theory of "leading vinegar-processing Chinese medicine into liver".At the same time, the research trend and idea of the effect mechanism of "leading vinegar-processing Chinese medicine into liver" based on the Quality markers(Q-Marker) of TCM, biological targets, and clinical prescriptions were put forward, providing references for the further study on "leading vinegar-processing Chinese medicine into liver".This paper also provided a scientific basis for the rational selection of processed products in TCM clinical practice.

关键词(KeyWords): 中药炮制;醋制入肝;科学内涵;研究进展;思路探讨
processing of Chinese medicine;leading vinegar-processing Chinese medicine into liver;scientific connotation;research progress;discussion on ideas

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81973483,82173975,81873008)

作者(Authors): 张倩;薛蓉;徐瑞杰;何天雨;苏联麟;张伟;李林;季德;毛春芹;陆兔林;
ZHANG Qian;XUE Rong;XU Rui-jie;HE Tian-yu;SU Lian-lin;ZHANG Wei;LI Lin;JI De;MAO Chun-qin;LU Tu-lin;School of Pharmacy, Nanjing University of Chinese Medicine;

DOI: 10.19540/j.cnki.cjcmm.20220307.301

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