中国中药杂志

2015, v.40(24) 4853-4859

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外翻肠囊法评价黄连-大黄药对不同提取工艺中生物碱的肠吸收特性
Evaluation on intestinal absorption of alkaloids extracted by different methods from Rhizoma Coptidis-Rheum rhabarum herbal pair via everted gut sacs

陈凯;王月亮;陈彦;李慧;刘宇灵;王佳奇;张晓莉;刘文丛;
CHEN Kai;WANG Yue-liang;CHEN Yan;LI Hui;LIU Yu-ling;WANG Jia-qi;ZHANG Xiao-li;LIU Wen-cong;Jilin Agricultural University College of Traditional Chinese Medicine;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Multi-component of Traditional Chinese Medicine and Microecology Research Center,Jiangsu Provincial Academy of Medical Sciences;

摘要(Abstract):

采用水煎和醇提2种工艺,通过大鼠肠外翻模型评价黄连-大黄配伍药对中生物碱的体外肠吸收特征。以小檗碱、巴马汀、黄连碱、表小檗碱4种主要生物碱成分为代表,采用一测多评法对其进行定量分析,计算吸收速率常数,进而评价2种工艺中,4种生物碱成分在大鼠不同肠段的体外吸收特征。结果显示:2种不同工艺提取物中上述4种成分的高、中、低剂量在小肠段均为线性吸收,R2大于0.99,符合零级吸收速率,小肠部位的吸收速率常数(K_a)表现为水煎组>醇提组。
The research aimed to evaluate the intestinal absorption of alkaloids extracted by decoction and alcohol extraction processes from Rhizoma Coptidis-Rheum rhabarum herbal pair via everted gut sacs. Berberine,palmatine,coptisine and epiberberine were the main alkaloids in this herbal pair and taken as the standard indexes in the quantitative analysis with multi-components by single marker( QAMS) method,in order to calculate absorption rate constant( Ka) and evaluate intestinal absorption characteristics of these four alkaloids extracted by different extraction methods in different intestinal segments in rats. The results showed that the four alkaloids extracted by two different processes in high,medium and low doses had linear absorption properties in the small intestine segment,which conformed to zero-order absorption rate,intestinal segment than 0. 99. The absorption rate constant( Ka) of decoction group was higher than that of alcohol extraction group.

关键词(KeyWords): 黄连;大黄;肠外翻;吸收速率常数(Ka)
Coptidis Rhizoma;Rhei Radix et Rhizoma;everted gut scas;absorption rate constant

Abstract:

Keywords:

基金项目(Foundation): 中国中医科学院自主选题项目(Z02063);; 2009年中医药行业科研专项(200907001-5)

作者(Authors): 陈凯;王月亮;陈彦;李慧;刘宇灵;王佳奇;张晓莉;刘文丛;
CHEN Kai;WANG Yue-liang;CHEN Yan;LI Hui;LIU Yu-ling;WANG Jia-qi;ZHANG Xiao-li;LIU Wen-cong;Jilin Agricultural University College of Traditional Chinese Medicine;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;Multi-component of Traditional Chinese Medicine and Microecology Research Center,Jiangsu Provincial Academy of Medical Sciences;

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