中国中药杂志

2020, v.45(14) 3379-3386

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基于牡丹皮道地性组分结构特征关联分析牡丹皮配方颗粒质量
Quality analysis of Moutan Cortex Formula Granules based on structural characteristics of genuine components

夏昀卿;李如;封亮;贾晓斌;
XIA Yun-qing;LI Ru;FENG Liang;JIA Xiao-bin;College of Pharmacy, Jiangsu University;School of Traditional Chinese Pharmacy, China Pharmaceutical University;

摘要(Abstract):

以牡丹皮道地性组分结构特征为基础,对不同厂家牡丹皮配方颗粒的质量进行评价。建立了牡丹皮配方颗粒HPLC指纹图谱分析方法,采用该方法表征了道地牡丹皮组分结构特征的构成要素,标定了19个共有峰,各批次牡丹皮配方颗粒与对照指纹图谱的相似度为0.856~0.981,表明3个厂家生产的牡丹皮配方颗粒内在质量存在差异性。分析了不同厂家牡丹皮配方颗粒构成要素的含量、组分间以及组分内的量比关系,发现A厂家生产的样品G1,G2与B厂家生产的样品G4组分间量比关系比较接近,B厂家样品G3与C厂家样品G7组分间量比关系更为接近,C厂家生产的样品G5,G6,G8~G11组分间量比关系更为接近。"组分结构"理论为指导的研究结果,为牡丹皮配方颗粒质量评价提供了新的分析方法和探究基础。
To evaluate the quality of Moutan Cortex Formula Granules from different manufacturers based on the structural characteristics of the genuine components of Moutan Cortex. High performance liquid chromatography(HPLC) fingerprint analysis method of Moutan Cortex Formula Granules was established to characterize the elements of the structural characteristics for genuine Moutan Cortex. Nineteen common peaks were determined and the similarity between the Moutan Cortex Formula Granules of each batch and the control fingerprint was 0.856-0.981. The results showed that there were differences in the internal quality of Moutan Cortex Formula Granules from three manufacturers. The contents of components as well as inter-component and intra-component quantity ratio for Moutan Cortex Formula Granules from different manufacturers were analyzed. It was found that the inter-component quantity ratio of G1 and G2 produced by manufacturer A was close to that of G4 produced by manufacturer B; the inter-component quantity ratio of G3 from manufacturer B was close to that of G7 from manufacturer C; and the inter-component ratios of samples G5, G6, G8-G11 produced by manufacturer C were closer to each other. The results of the study guided by the theory of "component structure" provide a new analytical method and basis for the quality evaluation of Moutan Cortex Formula Granules.

关键词(KeyWords): 牡丹皮配方颗粒;指纹图谱;组分结构特征;质量控制
Moutan Cortex Formula Granules;fingerprint;structural characteristics of components;quality control

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基金项目(Foundation): 国家自然科学基金项目(81703775,81973536);; 中国药科大学双一流项目(CPU2018GF07,CPU2018GY11);; 河南宛西制药合作基金项目(8010020204)

作者(Author): 夏昀卿;李如;封亮;贾晓斌;
XIA Yun-qing;LI Ru;FENG Liang;JIA Xiao-bin;College of Pharmacy, Jiangsu University;School of Traditional Chinese Pharmacy, China Pharmaceutical University;

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