中国中药杂志

2010, v.35(15) 2004-2007

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藿香正气微乳与藿香正气水的急性毒性与药效比较研究
Comparative study on acute toxicity and pharmacological effect of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture

路艳丽;彭博;贺蓉;高杰;杨华;易红;李建荣;
LU Yanli,PENG Bo,HE Rong,GAO Jie,YANG Hua,YI Hong,LI Jiangrong(Institute of Chinese Materia Medica,Academy of Traditional Chinese Medicine,Beijing 100700,China)

摘要(Abstract):

目的:比较藿香正气微乳与藿香正气水2种剂型的急性毒性反应及主要药效学指标。方法:以最大给药量试验比较藿香正气微乳与藿香正气水对小鼠的急性毒性反应;采用番泻叶诱导小鼠腹泻模型,以腹泻指数、胃泌素、胃动素为指标,以ED50值为标准,比较2种剂型的止泻作用强度。结果:藿香正气水对小鼠的急性毒性明显高于藿香正气微乳;藿香正气微乳与藿香正气水的ED50值相近。结论:藿香正气微乳的安全性明显高于藿香正气水;藿香正气微乳对番泻叶腹泻模型小鼠的止泻作用与藿香正气水基本相当。
Objective:To compare the acute toxicity and the pharmacological effect of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture.Method:The acute toxicities of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture were observed by the test of maximum dose in mice and the antidiarrheal effects of them were evaluated by ED50 values of the diarrhea index,the serum levels of gastrin and motilin in the mice diarrhea model induced by senna.Result:The acute toxicity of Huoxiang Zhengqi tincture was much higher than that of Huoxiang Zhengqi microemulsion and the ED50 values of the two formulations were similar.Conclusion:The microemulsion of Huoxiang Zhengqi prescription was much safer than that of tincture,but the antidiarrheal effects of them in diarrhea model induced by senna were similar.

关键词(KeyWords): 藿香正气微乳;藿香正气水;小鼠腹泻模型;腹泻指数;胃泌素;胃动素
Huoxiang Zhengqi microemulsion;Huoxiang Zhengqi tincture;mice diarrhea model;diarrhea index;gastrin;motilin

Abstract:

Keywords:

基金项目(Foundation): 国家“十一五”科技支撑计划(2006BAI09B08-15);; 国家自然科学基金项目(30472195);; “重大新药创制”科技重大专项(2009ZX09301-005-05)

作者(Author): 路艳丽;彭博;贺蓉;高杰;杨华;易红;李建荣;
LU Yanli,PENG Bo,HE Rong,GAO Jie,YANG Hua,YI Hong,LI Jiangrong(Institute of Chinese Materia Medica,Academy of Traditional Chinese Medicine,Beijing 100700,China)

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