中国中药杂志

2021, v.46(04) 782-785

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基于中西医临床病症特点的慢性皮肤溃疡动物模型分析
Analysis of animal models of chronic skin ulcers based on characteristics of clinical symptoms of traditional Chinese and Western medicine

吴瑞;李秀敏;苗明三;
WU Rui;LI Xiu-min;MIAO Ming-san;Henan University of Chinese Medicine;

摘要(Abstract):

基于慢性皮肤溃疡中、西医临床病症特点,总结归纳目前现有的皮肤溃疡动物模型。该文根据慢性皮肤溃疡的病因病机、中西医诊断标准及观测指标,分析动物模型的优缺点,评价现有动物模型与慢性皮肤溃疡中、西医临床病证特点的吻合情况。经分析对比发现,目前已有的造模方法中,多为单因素动物模型,与临床多因素、相互作用共同导致慢性皮肤溃疡的生理病理特点存在一定差距,且造模方法多以西医为指导,在造模过程中缺少中医致病因素。因此,该文建议建立合理的慢性皮肤溃疡动物模型量化标准,把建立具有中西医病症特的慢性皮肤溃疡病证结合模型作为未来动物模型研究的重点。
Based on the characteristics of clinical symptoms of chronic skin ulcers in traditional Chinese and Western medicine, the current animal models of skin ulcers are summarized. This article analyzes the advantages and disadvantages of animal models according to the etiology and pathogenesis of chronic skin ulcers, traditional Chinese and Western medicine diagnostic criteria and observation indicators, and eva-luates the agreement between the existing animal models and the characteristics of clinical syndromes of traditional Chinese and Western medicine for chronic skin ulcers. Through analysis and comparison, it is found that most of the existing modeling methods are single-factor animal models, and there are certain gaps in the physiological and pathological characteristics of chronic skin ulcers caused by clinical multi-factors and interactions. Most of the modeling methods are guided by Western medicine. The lack of pathogenic factors of traditional Chinese medicine(TCM) in the process of modeling. Therefore, this article proposes to establish a reasonable quantification standard for chronic skin ulcer animal models, and to establish a combination model of chronic skin ulcer disease with traditional Chinese and Western medicine as the focus of future animal model research.

关键词(KeyWords): 慢性皮肤溃疡;病症结合;动物模型
chronic skin ulcer;combination of disease;animal model

Abstract:

Keywords:

基金项目(Foundation): 国家国际合作基地项目(2016-65);; 河南省杰出外籍科学家工作室项目(GZS2019006);; 中原学者项目(162101510003)

作者(Author): 吴瑞;李秀敏;苗明三;
WU Rui;LI Xiu-min;MIAO Ming-san;Henan University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20200918.601

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