中国中药杂志

2007, (21) 2217-2222

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中药淫羊藿主要资源种类药材质量的系统研究
Systematic studies on quality of main species of Herba Epimedii

裴利宽;黄文华;何天谷;郭宝林;
PEI Li-kuan1,HUANG Wen-hua1,HE Tian-gu2,GUO Bao-lin1(1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094,China;2.The Hospital of Yangliu Town,Yinjiang County,Yinjiang 555212,China)

摘要(Abstract):

目的:为有效实现淫羊藿药材质量控制,考察药典中规定的淫羊藿Epimedium brevicornu,箭叶淫羊藿E. sagittatum,柔毛淫羊藿E. pubescens,朝鲜淫羊藿E. koreanum和巫山淫羊藿E. wushanense等5个种,以及《贵州省中药材、民族药材标准》收载的粗毛淫羊藿E. acuminatum,天平山淫羊藿E. myrianthum,黔岭淫羊藿E. leptorrhizum3个种,以及贵州省作为巫山淫羊藿使用的拟巫山淫羊藿E. pseudowushanuse共9个主要资源种类的药材质量情况。方法:采用HPLC,UV测定共102份不同产地的上述9种淫羊藿药材样本的淫羊藿苷、总黄酮含量,并测定了以淫羊藿苷为参照的朝藿定A,B,C和淫羊藿苷(简称淫羊藿多苷,ABCI)4种成分的总量。结果和结论:以药典5个品种样品计,仅约有30%的样本淫羊藿苷含量达到药典标准,本研究提出以淫羊藿多苷的总量不低于1.3%,总黄酮含量不低于5.0%作为淫羊藿药材质量控制指标,并对各品种进行了质量评价,提出这些品种作为国家标准的参考意见。
Objective: To achieve the quality control of Herba Epimedii,and to evaluate the quality of medical materials of the 8 official species including the 5 species recorded in 'Chinese Pharmacopoeia' including Epimedium brevicornum,E.sagittatum,E.pubescens,E.koreanum and E.wushanense,and the 3 other species(E.acuminatum,E.myrianthum,E.leptorrhizum) recorded in 'Guizhou Quality Criteria for Traditional Chinese Medical Material and Nationality Medical Material',and E.pseudowushanuse(new speccies) which is used as E.wushanense for a long time.Method: The contents of icariin and total flavonoids of 102 samples of 9 officinal species of Herba Epimedii were determined by HPLC and UV,respectively.Result and Conclusion: The contents of icariin in about 30% of the samples of the 5 species recorded in 'Chinese Pharmacopoeia' were lower than 0.5%,which is acceptable quality recorded in 'Chinese Pharmacopoeia'.Refering the literatures,we suggested the total contents of epimedin A,B,C and icariin(epimedium multi-glycosides,ABCI) should be established as a new standard instead of the content of icariin.The content of total flavonoids,not less than 5.0%,and ABCI,not less than 1.3%,could be used to evaluate the quality of the above medical materials efficiently.

关键词(KeyWords): 淫羊藿药材;淫羊藿多苷;淫羊藿苷;HPLC;总黄酮;UV;质量控制
Herba Epimedii;epimedium multi-glycosides;icariin;HPLC;total flavonoids;UV;quality control

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基金项目(Foundation): 国家自然科学基金项目(30270101)

作者(Author): 裴利宽;黄文华;何天谷;郭宝林;
PEI Li-kuan1,HUANG Wen-hua1,HE Tian-gu2,GUO Bao-lin1(1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094,China;2.The Hospital of Yangliu Town,Yinjiang County,Yinjiang 555212,China)

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