中国中药杂志

2020, v.45(14) 3351-3359

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牡丹皮道地性物质基础组分结构特征研究
Structural characteristics of pharmacodynamical components in genuine Moutan Cortex

夏昀卿;朱毛毛;李如;杨立诚;高松;曹素梅;封亮;贾晓斌;
XIA Yun-qing;ZHU Mao-mao;LI Ru;YANG Li-cheng;GAO Song;CAO Su-mei;FENG Liang;JIA Xiao-bin;College of Pharmacy, Jiangsu University;School of Traditional Chinese Pharmacy, China Pharmaceutical University;Nanjing Institute of Product Quality Inspection;Henan Wanxi Pharmaceutical Co., Ltd.;

摘要(Abstract):

该实验以"组分结构"理论为指导,分析道地牡丹皮的物质基础组分结构特征。对20批道地牡丹皮与12批非道地牡丹皮样品,采用HPLC分析表征了有机小分子物质组成,通过相似度分析、聚类分析、主成分分析以及正交偏最小二乘-判别分析,提炼出物质基础组分结构特征的构成要素,包括萜苷组分(氧化芍药苷、芍药苷、没食子酰芍药苷、苯甲酰氧化芍药苷、苯甲酰芍药苷)、鞣质组分(1,3,6-三-O-没食子酰葡萄糖、五没食子酰葡萄糖)、酚酸组分(没食子酸甲酯、丹皮酚);分析了道地牡丹皮中萜苷组分、鞣质组分、酚酸组分之间的量和量比关系分别为14.1,12.5,21.7 mg·g~(-1),1.00∶0.89∶1.54;萜苷组分中成分氧化芍药苷、芍药苷、苯甲酰芍药苷之间的量与量比关系具有特征性,分别为2.05,7.05,3.30 mg·g~(-1),1.00∶3.44∶1.61。道地牡丹皮独特的组分结构特征为其优质质量标准的制订提供了科学依据。
Guided by the theory of "component structure", we analyzed the structural characteristics of pharmacodynamical components in genuine Moutan Cortex. The compositions of organic small molecules were determined by high performance liquid chromatography(HPLC) for 20 batches of genuine Moutan Cortex and 12 batches of non-genuine Moutan Cortex. By means of similarity analysis, clustering analysis(CA), principal component analysis(PCA) and orthogonal partial least-squares discriminant analysis(OPLS-DA), the elements in structural characteristics of the pharmacodynamical components were extracted as follows: terpene glycosides components(oxidized paeoniflorin, paeoniflorin,galloyl paeoniflorin, benzoyloxy paeoniflorinand benzoyl paeoniflorin), tannin components(1,3,6-tri-O-galloside acyl glucose, pentagalloyl glucose), and phenolic acid components(methyl gallate, paeonol). The contents and quantity ratios of terpene glycoside component, tannin component and phenolic acid components in genuine Moutan Cortex were determined as 14.1, 12.5, 21.7 mg·g~(-1), 1.00∶0.89∶1.54. The contents and quantity ratios of the oxidized paeoniflorin, paeoniflorin and benzoylpaeoniflorin in the terpene glycoside components were characteristic and determined as 2.05, 7.05, 3.30 mg·g~(-1), 1.00∶3.44∶1.61. The unique structural characteristics of genuine Moutan Cortex provide scientific basis for the formulation of quality standards.

关键词(KeyWords): 牡丹皮;道地性;物质基础;组分结构特征
Moutan Cortex;genuine;pharmacodynamical basis;structural characteristics of components

Abstract:

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基金项目(Foundation): 国家自然科学基金项目(81703775,81973536);; 中国药科大学双一流项目(CPU2018GF07,CPU2018GY11);; 河南宛西制药合作基金项目(8010020204)

作者(Author): 夏昀卿;朱毛毛;李如;杨立诚;高松;曹素梅;封亮;贾晓斌;
XIA Yun-qing;ZHU Mao-mao;LI Ru;YANG Li-cheng;GAO Song;CAO Su-mei;FENG Liang;JIA Xiao-bin;College of Pharmacy, Jiangsu University;School of Traditional Chinese Pharmacy, China Pharmaceutical University;Nanjing Institute of Product Quality Inspection;Henan Wanxi Pharmaceutical Co., Ltd.;

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