中国中药杂志

2010, v.35(20) 2674-2678

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O/O型葛根素纳米乳在大鼠体内吸收转运机制及粒径相关性研究
Absorption transport mechanism of puerarin oil-in-oil nanoemulsion

潘恩媛;吴鸿飞;鲁传华;桂双英;王蕾;
PAN Enyuan,WU Hongfei,LU Chuanhua*,GUI Shuangying,WANG Lei(Anhui Province Key Laboratory of Research﹠Development of Chinese Medicine,Anhui University of Traditional Chinese Medicine,Hefei 230038,China)

摘要(Abstract):

目的:研究O/O型纳米乳经胃肠道吸收转运及其粒径相关性。方法:采用大鼠胸导管插管术同时眼眶取血的方法,比较淋巴管阻断及未阻断下大鼠体内血药浓度的变化,考察大鼠灌胃葛根素纳米乳后胃肠道的生物转运效率、主要转运途径和体内血药浓度经时变化规律、以及不同粒径的纳米乳对淋巴吸收转运效率的影响。结果:葛根素口服纳米乳经胃肠道生物转运途径中约有36.8%的药物经淋巴途径转运进入体循环;纳米乳经淋巴途径吸收转运的程度与粒径的大小成反比。结论:O/O型葛根素纳米乳平均约有1/3经淋巴途径、2/3经非淋巴途径吸收进入体循环,经淋巴转运的效率与粒径相成反比。
Objective: To investigate the mechanisms of the oil-in-oil nanoemulsions transport through the gastrointestinal tract and the transport efficiency changed with its different particle size in the lymphatic channels.Method: The behavior of nanoemulsions in vivo and their absorption via lymph after oral administartion was investigated,with the transport efficiency and absorption pathway of nanoemulsions clarified by lymph duct cannulation in rats.Result: It suggested about 36.8% of puerarin nanoemulsions was transported into systematic circulation via lymph.Nanoparticles with different size absorbed by the lymphatic channels varied as the degree of transportion.Conclusion: The degree of absorption and particle transport is inversely proportional to the size.

关键词(KeyWords): O/O型纳米乳;葛根素;不同粒径;淋巴途径吸收
oil-in-oil nanoemulsion;puerarin;different particle size;lymphatic channel

Abstract:

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基金项目(Foundation): 安徽中医学院自然科学研究基金项目(2010ZR012B);; 安徽省2008年度科技计划项目(08020303080)

作者(Author): 潘恩媛;吴鸿飞;鲁传华;桂双英;王蕾;
PAN Enyuan,WU Hongfei,LU Chuanhua*,GUI Shuangying,WANG Lei(Anhui Province Key Laboratory of Research﹠Development of Chinese Medicine,Anhui University of Traditional Chinese Medicine,Hefei 230038,China)

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