李外;吴子薇;李晓波;陈艳;王梦月;
LI Wai;WU Zi-wei;LI Xiao-bo;CHEN Yan;WANG Meng-yue;Department of Pharmacy, Medical Supplies Centre of PLA General Hospital;School of Pharmacy, Shanghai Jiao Tong University;

• 1:中国人民解放军总医院医疗保障中心药剂科
• 2:上海交通大学药学院

摘要(Abstract)：

采用硅胶柱色谱、制备HPLC、NMR、HR-MS等方法，首次对异株荨麻果实的化学成分进行了研究。结果从中分离鉴定了21个成分：7R,8S,8′R-橄榄脂素(1)、油酸(2)、α-亚油酸(3)、棕榈酸(4)、棕榈酸甲酯(5)、α-亚麻酸(6)、α-亚麻酸甲酯(7)、5-O-咖啡酰基莽草酸(8)、香草酸(9)、对香豆酸(10)、5-O-对香豆酰基莽草酸(11)、肉桂酸(12)、奎宁酸(13)、莽草酸(14)、咖啡酸乙酯(15)、阿魏酸松柏酯(16)、阿魏酸(17)、咖啡酸(18)、绿原酸(19)、松脂酚(20)、槲皮素(21)。其中，化合物1为新化合物，化合物2～16均为首次从异株荨麻中分离得到。
The chemical constituents in Urtica dioica fruits were investigated by silica gel chromatography, preparative HPLC, NMR, and HR-MS for the first time. As a result, 21 compounds were isolated from the fruits of U. dioica and identified 7R,8S,8′R-olivil(1), oleic acid(2), α-linoleic acid(3), palmic acid(4), methyl palmitate(5), α-linolenic acid(6), α-linolenic acid methyl ester(7), 5-O-caffeoyl-shikimic acid(8), vanillic acid(9), p-coumaric acid(10), 5-O-p-coumaroylshikimic acid(11), cinnamic acid(12), quinic acid(13), shikimic acid(14), ethyl caffeate(15), coniferyl ferulate(16), ferulic acid(17), caffeic acid(18), chlorogenic acid(19), pinoresinol(20), and quercetin(21). Compound 1 was a new compound and compounds 2-16 were isolated from U. dioica for the first time.

关键词(KeyWords)： 异株荨麻;果实;有机酸;木脂素;化学成分
Urtica dioica;fruit;organic acid;lignan;chemical constituent

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81374067);; 上海市自然科学基金项目(20ZR1427700);; 上海市卫计委项目(2018YP002)

作者(Authors): 李外;吴子薇;李晓波;陈艳;王梦月;
LI Wai;WU Zi-wei;LI Xiao-bo;CHEN Yan;WANG Meng-yue;Department of Pharmacy, Medical Supplies Centre of PLA General Hospital;School of Pharmacy, Shanghai Jiao Tong University;

DOI: 10.19540/j.cnki.cjcmm.20220413.201

参考文献(References)：

• [1] European Directorate for the Quality Control of Medicines.European Pharmacopoeia 9.0 [Z].Strasbourg,2016:1450.
• [2] The United States Pharmacopeial Convention.United States Pharmacopoeia (39) [Z].New York,2016:6853.
• [3] GRAUSO L,FALCO B D,LANZOTTI V,et al.Stinging nettle,Urtica dioica L.:botanical,phytochemical and pharmacological overview [J].Phytochem Rev,2020,19 (6):1341.
• [4] 苏日娜，罗维早，朱继孝，等.荨麻属药用植物研究进展[J].中草药，2018,49(11):2722.
• [5] SAKURAI N,NAGASHIMA S I,KAWAI K I,et al.A new lignan,(-)-berchemol,from Berchemia racemosa [J].Chem Pharm Bull,1989,37(12):3311.
• [6] XU Y H,WANG Q H,BAO W Q,et al.Antihyperlipidemic effect,identification and isolation of the lipophilic components from Artemisia integrifolia [J].Molecules,2019,24:725.
• [7] 廖铁松，沈云亨，李影，等.巴西甘菊花化学成分研究(Ⅱ)[J].中药材，2019,42(11):2551.
• [8] 高彬，黎贵凤，孙侨生，等.鱼腥草肝细胞毒性及化学成分研究[J].中国中医药科技，2021,28(4):564.
• [9] 任英杰，曹彦刚，曾梦楠，等.薯蓣茎叶化学成分研究[J].中国药学杂志，2021,56(12):963.
• [10] ADAM K P.Phenolic constituents of the fern Phegopteris connectilis [J].Phytochemistry,1999,52(5):929.
• [11] HAIKAL A,EL-NEKETI M,ELSHAER S,et al.Mentha longifolia subsp.typhoides and subsp.schimperi:antimicrobial and antiquorum-sensing bioactivities [J].Chem Nat Compd,2021,57(5):933.
• [12] 颜朦朦，肖世基，丁立生，等.北栽秧花化学成分研究[J].中草药，2014,45(3):314.
• [13] 黄乐怡，孙煜铮，陈倩倩，等.白花败酱的化学成分研究[J].中草药，2021,52(23):7088.
• [14] 牛研，王书芳.当归中一个新苯酞类化合物[J].中国中药杂志，2014,39(1):80.
• [15] 张浩，陈艳，李晓波，等.荨麻抑制前列腺增生作用物质基础研究[J].中国中药杂志，2022,47(2):419.