野八角化学成分的研究
投稿时间:1900-01-01  修订日期:1900-01-01  责任编辑:  点此下载全文
引用本文:尚小雅,郭妙茹,赵琮玮,李帅.野八角化学成分的研究[J].中国中药杂志,2008,33(21):2490.
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尚小雅  郭妙茹  赵琮玮  李帅
1. 北京联合大学 生物活性物质与功能食品北京市重点实验室, 北京 100083;
2. 中国医学科学院 中国协和医科大学 药物研究所 中草药物质基础与资源利用教育部重点实验室,
北京 100050
中文摘要:目的:研究野八角Illicium simonsii乙醇粗提物中显示抗艾滋病毒活性部位的化学成分。方法:应用各种色谱技术进行分离纯化,用MS和NMR分析鉴定化合物结构。结果:从野八角90%乙醇提取物的抗艾滋病毒活性部位分离得到7个化合物,分别鉴定为(+)-儿茶精(1),(-)-表儿茶精(2),(+)-儿茶精3-O-α-L-鼠李糖苷(3),山柰素3-O-α-L-鼠李糖苷(4),槲皮素3-O-α-L-鼠李糖苷(5),3,5-二甲氧基-4-羟基苯甲酸-7-O-β-D-吡喃葡萄糖苷(6)和胡萝卜苷(7)。结论:以上7个化合物均为首次从该植物中分离得到,化合物3,6是首次从该属植物中发现,但均未显示抗艾滋病毒活性。
中文关键词:野八角  抗艾滋病毒活性  化学成分
 
Studies on chemical constituents of Illicium simonsii
SHANG Xiao-ya; GUO Miao-ru; ZHAO Cong-wei; LI Shuai*
1. Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Arts & Science of
Beijing Union University, Beijing 100083, China;
2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica,
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:Objective: To study the chemical constituents from the active fractions against HIV in vitro, a crude ethanolic extract of Illicium simonsii. Method: The compounds were isolated with column chromatography methods. MS and NMR spectroscopic methods were used to determine the structures of the compounds. Result: Seven compounds were isolated from the active fractions against HIV in vitro of the 90% ethanol extract and their structures were elucidated as (+)-catechin (1), (-)-epicatechin (2), (+)-catechin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-rhamnopyranoside (4), quercetin 3-O-α-L-rhamnopyranoside (5), erigeside C (6) and daucosterol (7). Conclusion: Seven compounds were isolated from this plant for the first time, but none of them exhibited active against HIV in vitro. Compounds 3 and 6 were isolated from this genus for the first time.
keywords:Illicium simonsii  anti-HIV activity  chemical constituents
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