中药对神经干细胞增殖分化信号通路的综合调控作用分析
投稿时间:2017-08-05    责任编辑:  点此下载全文
引用本文:汪宏锦,李晶晶,柯慧,徐晓玉.中药对神经干细胞增殖分化信号通路的综合调控作用分析[J].中国中药杂志,2017,42(21):4093.
DOI:
摘要点击次数: 67
全文下载次数: 34
           
作者中文名作者英文名单位中文名单位英文名E-Mail
汪宏锦 WANG Hong-jin 西南大学 药学院&中医药学院 重庆市高校中药新药筛选重点实验室 国家中医药管理局中药药理学重点建设学科, 重庆 400715 Key Discipline Constructed by State Administration of Traditional Chinese Medicine, Chongqing Key Laboratory of Screening of New Traditional Chinese Medicine, School of Pharmacology of Chinese Materia Medica, Southwest University, Chongqing 400715, China  
李晶晶 LI Jing-jing 西南大学 药学院&中医药学院 重庆市高校中药新药筛选重点实验室 国家中医药管理局中药药理学重点建设学科, 重庆 400715 Key Discipline Constructed by State Administration of Traditional Chinese Medicine, Chongqing Key Laboratory of Screening of New Traditional Chinese Medicine, School of Pharmacology of Chinese Materia Medica, Southwest University, Chongqing 400715, China  
柯慧 KE Hui 西南大学 药学院&中医药学院 重庆市高校中药新药筛选重点实验室 国家中医药管理局中药药理学重点建设学科, 重庆 400715 Key Discipline Constructed by State Administration of Traditional Chinese Medicine, Chongqing Key Laboratory of Screening of New Traditional Chinese Medicine, School of Pharmacology of Chinese Materia Medica, Southwest University, Chongqing 400715, China  
徐晓玉 XU Xiao-yu 西南大学 药学院&中医药学院 重庆市高校中药新药筛选重点实验室 国家中医药管理局中药药理学重点建设学科, 重庆 400715 Key Discipline Constructed by State Administration of Traditional Chinese Medicine, Chongqing Key Laboratory of Screening of New Traditional Chinese Medicine, School of Pharmacology of Chinese Materia Medica, Southwest University, Chongqing 400715, China xuxiaoyu@swu.edu.cn 
基金项目:国家自然科学基金面上项目(81473549);教育部中央高校基本科研业务费(XDJK2017E158)
中文摘要:寻找促进神经干细胞增殖与分化的有效方法是加速神经干细胞临床应用的途径之一。该文分析了近十年来中外文献关于调控神经干细胞增殖分化的中药及其作用靶点与信号通路的报道,发现中药对神经干细胞增殖分化信号通路具有综合调控作用。第一,中药能通过Notch,PI3K/Akt,Wnt/β-catenin,GFs等信号通路影响神经干细胞的增殖与分化。①黄芪、淫羊藿、龟甲、远志能通过调节Notch信号通路中的关键蛋白或基因Notch1,NICD和Hes的表达起调控作用;②人参、银杏叶、丹参能通过介导PI3K/Akt信号通路发挥调控作用,但对该通路中上下游靶标的具体作用机制尚无研究;③姜黄、蛇床子可以上调Wnt/β-catenin信号通路中的关键靶蛋白Wnt3a及β-catenin的水平从而介导Wnt/β-catenin信号通路起调控作用;④三七、川芎可以通过促进分泌性生长因子EGF,bFGF等的表达发挥作用。第二,一些中药能通过多种途径诱导神经干细胞的增殖或分化:黄芪中的黄芪甲苷可以通过Notch信号通路调控神经干细胞的增殖或分化,但黄芪多糖含药血清又可以通过调节VEGF含量,活化PI3K/Akt信号通路发挥作用;淫羊藿中的淫羊藿苷和淫羊藿黄酮类可以分别介导Notch或GFs信号通路来控制神经干细胞的命运转化;人参皂苷Rg1可以通过Notch和PI3K/Akt信号通路发挥调控作用;银杏内酯B可通过激活PI3K/Akt信号通路、上调HIF-1α表达来有效调节神经干细胞凋亡相关基因和促进细胞增殖与分化,进而起到神经保护作用,而银杏叶提取物也能通过上调多种细胞因子的释放促进神经干细胞的增殖与分化;姜黄素可以通过Wnt/β-catenin与Notch信号通路来调控神经干细胞的增殖与分化。第三,信号通路的串话(cross-talk)是一些中药发挥促NSCs增殖与分化的重要途径。Notch与GFs信号通路、GFs与PI3K/Akt信号通路、Notch与Wnt/β-catenin信号通路等在调控神经干细胞的过程中相互协调,相互制约,在中药促进神经干细胞增殖或分化中发挥着关键的作用。中药对调控神经干细胞增殖分化信号通路的串话研究有待进一步加深,阐明其多靶点和多途径的作用机制与综合调控作用。
中文关键词:神经干细胞  增殖  分化  中药  信号通路  串话
 
Comprehensive regulation effect of traditional Chinese medicine on proliferation and differentiation of neural stem cells
Abstract:Since the discovery of neural stem cells(NSCs) in embryonic and adult mammalian central nervous systems, new approaches for proliferation and differentiation of NSCs have been put forward. One of the approaches to promote the clinical application of NSCs is to search effective methods to regulate the proliferation and differentiation. This problem is urgently to be solved in the medical field. Previous studies have shown that traditional Chinese medicine could promote the proliferation and differentiation of NSCs by regulating the relevant signaling pathway in vivo and in vitro. Domestic and foreign literatures for regulating the proliferation and differentiation of neural stem cells in recent 10 years and the reports for their target and signaling pathways were analyzed in this paper. Traditional Chinese medicine could regulate the proliferation and differentiation of NSCs through signaling pathways of Notch, PI3K/Akt, Wnt/β-catenin and GFs. However, studies about NSCs and traditional Chinese medicine should be further deepened; the mechanism of multiple targets and the comprehensive regulation function of traditional Chinese medicine should be clarified.
keywords:neural stem cell  proliferation  differentiation  traditional Chinese medicine  signaling pathways  cross-talk
查看全文   下载PDF阅读器
相关阅读
评论
zuo-jiat you-jiat