黄芪皂甙对离体工作心脏的肌力作用及其可能机制
投稿时间:1991-02-02    责任编辑:  点此下载全文
引用本文:王奇玲;李云义;齐辉;孙晓霞;张文杰;江岩.黄芪皂甙对离体工作心脏的肌力作用及其可能机制[J].中国中药杂志,1992,17(09):557.
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王奇玲;李云义;齐辉;孙晓霞;张文杰;江岩
吉林省长春市中心医院,130041;白求恩医科大学,长春130021
中文摘要:黄芪皂甙AMS,50~200μg/ml对离体工作鼠心有正性肌力作用,30μg/ml呈负性肌力作用,洗脱后恢复。毒毛旋花子甙K与高浓度AMS作用相似。AMS 500μg/ml使培养鼠心肌细胞静息电位减小10mV。提示AMS通过Na-K-ATP酶实现强心作用。
中文关键词:  白求恩医科大学  长春130021
 
Inotropic Action of Astragalus membranaceus Bge. Saponins and Its Possible Mechanism
Abstract:Astragalus membranaceus saponins (AMS) 50~200μg/ml had a positive inotropic action on the isolated working heart of rats, but in the case of 30 μg/ml the inotropic action turned negative. The contractility recovered after washing out the AMS. Strophanthin K performed in a similar manner as AMS. AMS 500 μg/ml decreased the resting potential of cultured rat heart cells by 10 mV. The results suggest that AMS plays its inotropie role through influencing the Na-K-ATPase.
keywords:Astragalus membranaceus saponins  isolated working heart  cultured cardiomyocvtes  inotropic action  resting potentials
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