代谢组学在中医药复杂理论体系研究中的应用
投稿时间:2005-02-10    责任编辑:  点此下载全文
引用本文:贾伟;蒋健;刘平;赵立平;陈闽军;周明眉;杨丽萍;王米渠;邱明丰;张永煜.代谢组学在中医药复杂理论体系研究中的应用[J].中国中药杂志,2006,31(08):621.
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贾伟;蒋健;刘平;赵立平;陈闽军;周明眉;杨丽萍;王米渠;邱明丰;张永煜
中文摘要:新兴学科代谢组学的出现,给中医药复杂理论体系的研究、中医药现代化提供了强有力的研究手段。中医病证引起代谢物组的共性分析和生物标记物的发现,可促进“证”本质的研究、中医辨证的科学化和定量化,深层次理解中医脏象理论,预测疾病的发生,整体性评价中药复方综合疗效、安全性和作用机制,反应肠道内生态环境状况。代谢组学和中医药学的结合,将探索出中医药复杂理论体系研究的新方法与新途径。
中文关键词:代谢组学  中医药复杂理论系统  辨证论治  脏象理论  中药方剂  肠道菌群微生态学
 
Application of metabonomics in complicated theory system research of traditional Chinese medicine
JIA Wei ;LIU Ping ;JIANG Jian ;CHEN Min-jun ;ZHAO Li-ping ;ZHOU Ming-mei ;YANG Li-ping ;WANG Mi-qu ;QIU Mingfeng ;ZHANG Yong-yu
Abstract:Metabonomics,a new and rapid-developing technology,will be powerful means to the research of complexed theory system and modernization of traditional Chinese medicine(TCM).Discovery of biomarkers and analysis of common properties from the metabolome of a specific TCM syndrome will facilitate the modernized study of TCM system,promote the quantitative and scientific elucidation of TCM syndrome differentiation,provide an in-depth understanding of the TCM theory of Zang-xiang,help predict the disease on-set,and achieve a comprehensive evaluation of systemic clinical efficacy,safety and mechanism of action of the TCM combination formulas along with a better understanding of intestinal microflora ecology.The new approach with combined metabonomics and TCM methodologies will provide a new pathway and methodology for the study of complicated theory system of TCM and its modernization.
keywords:metabonomics  complexed theory system of TCM  treatment based on syndrome differentiation  Zang-xiang theory  intestinal microflora ecology
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