Network pharmacology study on major active compounds of Fufang Danshen formula
Received: August 03, 2011  
DOI:10.4268/cjcmm20112102
KeyWord:network pharmacology  Fufang Danshen formula  network traditional Chinese medicine pharmacology  coronary heart disease  diabetes mellitus
AuthorInstitutionE-mail
LI Xiang Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China  
WU Leihong Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China  
FAN Xiaohui Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China  
ZHANG Boli State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
GAO Xiumei State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
WANG Yi Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China mysky@zju.edu.cn 
CHENG Yiyu Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China  
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Abstract:
      Objective: To investigate the correlations between multi-compounds of Fufang Danshen formula and their multi targets and multi diseases. Method: Literature knowledge of nine major active compounds from Fufang Danshen formula, including tanshinone ⅡA, salvianolic acid B, protocatechuic aldehyde, danshensu, cryptotanshinone, notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1 and borneol were collected from PubMed. Combined with cardiovascular related diseases and genes from OMIM database, the corresponding multi-compound-multi- target-multi-disease network was constructed and visualized by Cytoscape software. Result and Conclusion: Network analysis showed that the 9 compounds could modulate 42 cardiovascular associated genes (e.g. PPARG, ACE, KCNJ11, KCNQ1, ABCC8, et al), which related to 30 cardiovascular associated diseases including non-insulin-dependent diabetes mellitus, hyperinsulinemic hypoglycemia, hypertension, and coronary heart disease. These results suggested new potential indications of Fufang Danshen formula.
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